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Lymphoproliferative disorders are a very heterogeneous group of neoplastic diseases, which originate from malignant transformation of cells of the lymphoid system. Within broad limits, they include at least four main types of diseases: Hodgkin’s disease, the socalled non-Hodgkin’s lymphomas, the chronic lymphoid leukemias and the neoplasms of mature B antibody-producing cells, such as Waldenström macroglobulinemia and multiple myeloma. Although many exceptions are recognized, the great variability of biological characteristics and clinical expression of lymphoproliferative disorders can be related to maturation arrests at different specific points in the normal ontogenic process of immunocompetent cells. Correlation of markers characteristics of malignant lymphocytes with those of normal cells is thus important for purposes of classification and can aid in diagnosis and prognosis. The complex nosology of lymphoproliferative disorders, moreover, does in fact tend to group diseases of similar clinical behavior, proliferative potential, preferential sites of involvement, natural history and response to therapy. The great majority of lymphoproliferative disorders encountered in the clinical practice are derived from B or T cells, most frequently at mature stages of their differentiation. The clinical characteristics of all these lymphomas demonstrate a wide range. Lymphomas with a follicular (or nodular) histological pattern of growth have a “low-grade” clinical behavior, European Review for Medical and Pharmacological Sciences